TFB1M explained
Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial enzyme that is encoded by the TFB1M gene.[1] [2] [3]
TFB1M is a mitochondrial methyltransferase, which uses S-adenosyl methionine to dimethylate two highly conserved adenosine residues at the 3'-end of the mitochondrial 12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[2] [4] [5]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an in vitro system containing recombinant mitochondrial RNA polymerase and TFAM.[6] There are no experimental data demonstrating that this function occurs in vivo; the paralogous TFB2M is more specific for this role.[7]
Interactions
TFB1M has been shown to interact with TFAM.[8]
Further reading
- Falkenberg M, Gaspari M, Rantanen A, etal . Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. . Nat. Genet. . 31 . 3 . 289–94 . 2002 . 12068295 . 10.1038/ng909 . 11164308 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Seidel-Rogol BL, McCulloch V, Shadel GS . Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. . Nat. Genet. . 33 . 1 . 23–4 . 2003 . 12496758 . 10.1038/ng1064 . 169443 .
- Rantanen A, Gaspari M, Falkenberg M, etal . Characterization of the mouse genes for mitochondrial transcription factors B1 and B2. . Mamm. Genome . 14 . 1 . 1–6 . 2003 . 12532263 . 10.1007/s00335-002-2218-z . 25379746 .
- McCulloch V, Shadel GS . Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. . Mol. Cell. Biol. . 23 . 16 . 5816–24 . 2003 . 12897151 . 10.1128/MCB.23.16.5816-5824.2003 . 166325 .
- Mungall AJ, Palmer SA, Sims SK, etal . The DNA sequence and analysis of human chromosome 6. . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . free . 2003Natur.425..805M .
- Bykhovskaya Y, Mengesha E, Wang D, etal . Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation. . Mol. Genet. Metab. . 82 . 1 . 27–32 . 2004 . 15110318 . 10.1016/j.ymgme.2004.01.020 .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Gleyzer N, Vercauteren K, Scarpulla RC . Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. . Mol. Cell. Biol. . 25 . 4 . 1354–66 . 2005 . 15684387 . 10.1128/MCB.25.4.1354-1366.2005 . 548005 .
- Cotney J, Wang Z, Shadel GS . Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression. . Nucleic Acids Res. . 35 . 12 . 4042–54 . 2007 . 17557812 . 10.1093/nar/gkm424 . 1919481 .
Notes and References
- Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
- McCulloch V, Seidel-Rogol BL, Shadel GS . A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine . Mol Cell Biol . 22 . 4 . 1116–25 . Jan 2002 . 11809803 . 134642 . 10.1128/MCB.22.4.1116-1125.2002 .
- Web site: Entrez Gene: TFB1M transcription factor B1, mitochondrial.
- Maria Falkenberg . Falkenberg M, Gaspari M, Rantanen A, etal . Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. . Nat. Genet. . 31 . 3 . 289–94 . 2002 . 12068295 . 10.1038/ng909 . 11164308 .
- Metodiev MD . Lesko N . Park CB . Camara Y. . Shi Y. . Wibom R. . Hultenby K. . Gustafsson CM . Larsson NG. . Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome . Cell Metab. . 9 . 4 . 386–97 . Apr 2009 . 19356719 . 10.1016/j.cmet.2009.03.001. free .
- Falkenberg M, Gaspari M, Rantanen A, etal . Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. . Nat. Genet. . 31 . 3 . 289–94 . 2002 . 12068295 . 10.1038/ng909 . 11164308 .
- Hillen . HS . Morozov . YI . Sarfallah . A . Temiakov . D . Cramer . P . Structural Basis of Mitochondrial Transcription Initiation. . Cell . 16 November 2017 . 171 . 5 . 1072–1081.e10 . 10.1016/j.cell.2017.10.036 . 29149603. 6590061 .
- 10.1128/MCB.23.16.5816-5824.2003 . McCulloch . Vicki . Shadel Gerald S . Aug 2003 . Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity . Mol. Cell. Biol. . 23 . 16 . 5816–24 . 0270-7306. 12897151 . 166325 .