POU4F2 explained
POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[1] [2]
Function
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]
Interactions
POU4F2 has been shown to interact with Estrogen receptor alpha.[3]
See also
Further reading
- Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB, Nathans J . The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons . The Journal of Neuroscience . 15 . 7 Pt 1 . 4762–85 . Jul 1995 . 7623109 . 10.1523/JNEUROSCI.15-07-04762.1995. 6577904 . free .
- Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB, Nathans J . Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells . Neuron . 11 . 4 . 689–701 . Oct 1993 . 7691107 . 10.1016/0896-6273(93)90079-7 . 33937730 .
- Bhargava AK, Li Z, Weissman SM . Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells . Proceedings of the National Academy of Sciences of the United States of America . 90 . 21 . 10260–4 . Nov 1993 . 8234287 . 47754 . 10.1073/pnas.90.21.10260 . 1993PNAS...9010260B . free .
- Smith MD, Dawson SJ, Latchman DS . Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor . The Journal of Biological Chemistry . 272 . 2 . 1382–8 . Jan 1997 . 8995448 . 10.1074/jbc.272.2.1382 . free .
- Budhram-Mahadeo V, Parker M, Latchman DS . POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element . Molecular and Cellular Biology . 18 . 2 . 1029–41 . Feb 1998 . 9448000 . 108815 . 10.1128/mcb.18.2.1029.
- Dennis JH, Budhram-Mahadeo V, Latchman DS . The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells . Oncogene . 20 . 36 . 4961–71 . Aug 2001 . 11526481 . 10.1038/sj.onc.1204491 . free .
- de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD . Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina . The Journal of Comparative Neurology . 461 . 2 . 187–204 . Jun 2003 . 12724837 . 10.1002/cne.10674 . 2862453 .
- Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS . Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor . Cancer Biology & Therapy . 3 . 3 . 317–23 . Mar 2004 . 14726699 . 10.4161/cbt.3.3.698 . free .
- Irshad S, Pedley RB, Anderson J, Latchman DS, Budhram-Mahadeo V . The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo . The Journal of Biological Chemistry . 279 . 20 . 21617–27 . May 2004 . 14970234 . 10.1074/jbc.M312506200 . free .
- Lee SA, Ndisang D, Patel C, Dennis JH, Faulkes DJ, D'Arrigo C, Samady L, Farooqui-Kabir S, Heads RJ, Latchman DS, Budhram-Mahadeo VS . Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter . Cancer Research . 65 . 8 . 3072–80 . Apr 2005 . 15833836 . 10.1158/0008-5472.CAN-04-2865 . free .
- Weishaupt JH, Klöcker N, Bähr M . Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells . Journal of Molecular Neuroscience . 26 . 1 . 17–25 . 2005 . 15968082 . 10.1385/JMN:26:1:017 . 528492 .
- Samady L, Faulkes DJ, Budhram-Mahadeo V, Ndisang D, Potter E, Brabant G, Latchman DS . The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells . International Journal of Cancer . 118 . 4 . 869–78 . Feb 2006 . 16152597 . 10.1002/ijc.21435 . 41744212 . free .
- Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP . Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes . Physiological Genomics . 25 . 1 . 9–15 . Mar 2006 . 16368877 . 10.1152/physiolgenomics.00121.2005 .
- Calissano M, Diss JK, Latchman DS . Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells . FEBS Letters . 581 . 13 . 2490–6 . May 2007 . 17490655 . 10.1016/j.febslet.2007.04.066 . 24033975 . free . 2007FEBSL.581.2490C .
Notes and References
- Ring CJ, Latchman DS . The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain . Nucleic Acids Research . 21 . 12 . 2946 . Jun 1993 . 8332509 . 309696 . 10.1093/nar/21.12.2946 .
- Web site: Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2.
- Budhram-Mahadeo V, Parker M, Latchman DS . POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element . Molecular and Cellular Biology . 18 . 2 . 1029–41 . Feb 1998 . 9448000 . 108815 . 10.1128/mcb.18.2.1029.