Nicaragua will participate in the 2011 Parapan American Games.
See main article: Athletics at the 2011 Parapan American Games. Nicaragua will send four male athletes to compete.
See main article: Goalball at the 2011 Parapan American Games. Nicaragua will send one team of six athletes to compete in the men's tournament.
See main article: Powerlifting at the 2011 Parapan American Games. Nicaragua will send one male athlete to compete.