LATS2 explained
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.[1] [2]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family and participates in the Hippo signaling pathway where it inactivates the effector proteins, YAP and WWTR1 (TAZ). The protein localizes to centrosomes during interphase and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.[2]
Further reading
- Hori T, Takaori-Kondo A, Kamikubo Y, Uchiyama T . Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. . Oncogene . 19 . 27 . 3101–9 . 2000 . 10871863 . 10.1038/sj.onc.1203659 . free .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Li Y, Pei J, Xia H, etal . Lats2, a putative tumor suppressor, inhibits G1/S transition. . Oncogene . 22 . 28 . 4398–405 . 2003 . 12853976 . 10.1038/sj.onc.1206603 . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Powzaniuk M, McElwee-Witmer S, Vogel RL, etal . The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. . Mol. Endocrinol. . 18 . 8 . 2011–23 . 2005 . 15131260 . 10.1210/me.2004-0065 . free .
- Toji S, Yabuta N, Hosomi T, etal . The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase. . Genes Cells . 9 . 5 . 383–97 . 2005 . 15147269 . 10.1111/j.1356-9597.2004.00732.x . free .
- Ke H, Pei J, Ni Z, etal . Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L). . Exp. Cell Res. . 298 . 2 . 329–38 . 2004 . 15265683 . 10.1016/j.yexcr.2004.04.031 .
- Chan EH, Nousiainen M, Chalamalasetty RB, etal . The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. . Oncogene . 24 . 12 . 2076–86 . 2005 . 15688006 . 10.1038/sj.onc.1208445 . 27285160 .
- Takahashi Y, Miyoshi Y, Takahata C, etal . Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. . Clin. Cancer Res. . 11 . 4 . 1380–5 . 2005 . 15746036 . 10.1158/1078-0432.CCR-04-1773 . free .
- Abe Y, Ohsugi M, Haraguchi K, etal . LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis. . FEBS Lett. . 580 . 3 . 782–8 . 2006 . 16413547 . 10.1016/j.febslet.2005.12.096 . free .
- Voorhoeve PM, le Sage C, Schrier M, etal . A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. . Cell . 124 . 6 . 1169–81 . 2006 . 16564011 . 10.1016/j.cell.2006.02.037 . free .
- Aylon Y, Michael D, Shmueli A, etal . A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. . Genes Dev. . 20 . 19 . 2687–700 . 2007 . 17015431 . 10.1101/gad.1447006 . 1578695 .
- Jiang Z, Li X, Hu J, etal . Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. . Neurosci. Res. . 56 . 4 . 450–8 . 2007 . 17049657 . 10.1016/j.neures.2006.09.006 . 22763208 .
Notes and References
- Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H . Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts . Genomics . 63 . 2 . 263–70 . Apr 2000 . 10673337 . 10.1006/geno.1999.6065 .
- Web site: Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila).