| Mode: | Women's basketball |
| Year: | 2012–13 |
| Team: | Louisville Cardinals |
| Short Conf: | Big East |
| Coachrank: | 2 |
| Aprank: | 16 |
| Record: | 29–9 |
| Conf Record: | 11–5 |
| Hc Year: | 6th |
| Asst Coach1: | Stephanie Norman |
| Asst Coach2: | Samantha Williams |
| Tourney Result: | Runner-up |
The 2012–13 Louisville Cardinals women's basketball team represented the University of Louisville during the 2012–13 NCAA Division I women's basketball season. The Cardinals, led by sixth-year head coach Jeff Walz, played their home games at the KFC Yum! Center as members of the Big East Conference before the conference would split. They finished the season 29–9, 11–5 in Big East play to land third in the regular season standings. They lost to Notre Dame in the semifinals of the Big East women's tournament. They received an at-large bid to the NCAA women's tournament. As the No. 5 seed in the Oklahoma City region, they defeated Middle Tennessee and Purdue to advance to the Sweet Sixteen. There they defeated No. 1 seed Baylor and No. 2 seed Tennessee in the Elite Eight to advance to the school's second Final Four. Playing as one of three Big East teams in the Final Four, they defeated Spokane regional champion California Golden Bears in the National semifinal round. In the National Championship, they lost to Connecticut.
|-!colspan=9 style=| Exhibition|-!colspan=9 style=| Regular season|-!colspan=9 style=| Big East Women's Tournament|-!colspan=9 style=| NCAA Women's TournamentSource[1]
See main article: 2012–13 NCAA Division I women's basketball rankings.